"Do you know .. is" ; "What say you?'

"Do you know what the matter with ...  is?"
vs
"Do you know what's the matter with ....?"

R.L.'s (individual) post:
http://groups.google.com/group/alt.usage.english/msg/a014477d8192ce4d

The thread:
http://groups.google.com/group/alt.usage.english/browse_thread/thread/656ad38ffb1c400?pli=1

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http://www.englishforums.com/English/WhatProblemProblem/jqjxv/post.htm

"What say you?"
http://www.learnersdictionary.com/blog.php?action=ViewBlogArticle&ba_id=105